Actigraphy-based sleep disruption and diurnal biomarkers of autonomic function in paroxysmal atrial fibrillation
Actigraphy-based measures of sleep disruption were associated with autonomic function alterations exhibiting diurnal variability in paroxysmal AF. Greater overall HRV and parasympathetic modulation were related to better sleep quality. Increased sympathetic activation was associated with sleep fragmentation. Results provide insights into differential autonomic dysfunction related to sleep disruption that may contribute to atrial arrhythmogenesis.
Authors
- Kenneth A. Loparo (ORCID: https://orcid.org/0000-0002-9286-7765)
- Sepideh Khazaie (ORCID: https://orcid.org/0000-0001-6007-1407)
- Farhad Kaffashi (ORCID: https://orcid.org/0000-0003-0416-7847)
- David R. Van Wagoner (ORCID: https://orcid.org/0000-0001-8250-9828)
- Catherine Heinzinger (ORCID: https://orcid.org/0000-0002-5407-0296)
- Reena Mehra (ORCID: https://orcid.org/0000-0002-6222-2675)
- Lu Wang (ORCID: https://orcid.org/0000-0003-1511-7108)
- Mina K. Chung
- Harneet K. Walia
Institutions
- Cleveland Clinic (US)
- Baptist Health South Florida (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Sleep And Breathing
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s11325-025-03293-4
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute