Pemafibrate modulates peroxisome proliferator-activated receptor alpha and prevents alcohol-associated liver disease in rats
The results of the present study demonstrated that pemafibrate modulates target genes related to hepatic lipid metabolism and prevents deposition of fat globules in the liver during chronic alcohol feeding in rats. Therefore, pemafibrate could be used as a potent therapeutic agent to prevent steatosis and related adverse events in ALD.
Authors
- Mutsumi Tsuchishima (ORCID: https://orcid.org/0000-0003-4634-5592)
- Kazuaki Ozaki
- Joseph George (ORCID: https://orcid.org/0000-0001-5354-7884)
- Mikihiro Tsutsumi (ORCID: https://orcid.org/0000-0003-0463-074X)
- Takashi Saito (ORCID: https://orcid.org/0000-0001-8049-1943)
Institutions
- Kanazawa Medical University (JP)
- Kanazawa Medical University Hospital (JP)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s10020-025-01210-9
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Kanazawa University
- Kanazawa Medical University