Genome-wide accumulations of non-random adaptive point mutations drive westward evolution of Helicobacter pylori
The lesser virulence of the westernized H. pylori is beneficial since this pathogen typically remains colonized in the stomach for decades before causing terminal diseases like gastric cancer. Moreover, the mutation-driven westward evolution of H. pylori is a global phenomenon, which occurred in the geographical regions where people from Eastern and Western ethnicities met and cohabited. The identified evolution of virulent Eastern H. pylori strains to lesser virulent Western variants by accumulation of point mutations also provides insight into the pathogenic potentials of different H. pylori strains.
Authors
- Jyoti Prakash Tamang (ORCID: https://orcid.org/0000-0003-0893-7896)
- Angitha N. Nath
- Pranav Chettri (ORCID: https://orcid.org/0000-0001-5464-1274)
- Parveen Sen (ORCID: https://orcid.org/0000-0003-2256-9380)
- Sanjit Biswas (ORCID: https://orcid.org/0000-0001-6393-9849)
- Naresh Kumar Agarwal (ORCID: https://orcid.org/0000-0003-0759-9450)
- Santanu Chattopadhyay (ORCID: https://orcid.org/0000-0002-6275-8568)
- Priya Dutta
- Namrata Thapa (ORCID: https://orcid.org/0000-0003-0819-3487)
- T. Barani Devi
- R. J. Retnakumar
- Sangey Chhophel Lamtha
- K. C. Sivakumar
Institutions
- National Institute of Technology Sikkim (IN)
- Manipal Academy of Higher Education (IN)
- Biotech Park (IN)
- Asian Institute of Gastroenterology (IN)
- Rajiv Gandhi Centre for Biotechnology (IN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s12866-025-03944-2
- Citations
- 1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Science and Engineering Research Board