Long non-coding RNA CYTOR promotes the progression of melanoma <i>via</i> the miR-485-5p/GPI axis
Our investigation identified a marked increase in CYTOR expression levels in both melanoma tissues and cells. Experiments conducted both <i>in vitro</i> and <i>in vivo</i> revealed that CYTOR markedly stimulated melanoma cell proliferation, migration, and invasion. Dual-luciferase reporter assays confirmed the direct binding of miR-485-5p to CYTOR, and glucose-6-phosphate isomerase (GPI) was identified as a direct target of miR-485-5p.
Authors
- Huanrong Hu
- Xinsuo Duan
- Xuefei Li (ORCID: https://orcid.org/0000-0003-0188-5667)
- Yanli Zhang (ORCID: https://orcid.org/0000-0002-8942-5325)
- Shang Ji
- Yaling Liu (ORCID: https://orcid.org/0000-0003-4321-399X)
- Yun-Hua Zhao
- Haitao Lu (ORCID: https://orcid.org/0000-0002-1772-764X)
- Shaomin Shi
- Haihua Qi
- Yandong Niu (ORCID: https://orcid.org/0009-0004-3288-9614)
Institutions
- Hebei Medical University (CN)
- Chengde Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-04-22
- DOI
- https://doi.org/10.7717/peerj.19284
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94