H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database

This study revealed that most severe AEs, such as anaphylaxis and toxic cutaneous diseases, caused by H1 antihistamines occurred within 1 week of treatment. Hepatotoxicity, alopecia, interstitial pneumonia, and aplastic anemia occurred throughout the treatment period.

Authors

Publication Details

Journal
International Journal of Clinical Pharmacology and Therapeutics
Published
2025-04-22
DOI
https://doi.org/10.5414/cp204707
Citations
1
Primary Topic
Drug-Induced Adverse Reactions
Type
article
Field-Weighted Citation Impact
1.39
Controls
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article

H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database

Tsuyoshi Shiga, Masayuki Hashiguchi, Mikako Takatsuka
1 citations
International Journal of Clinical Pharmacology and Therapeutics
Drug-Induced Adverse Reactions
1.39
article

H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database

Tsuyoshi Shiga, Masayuki Hashiguchi, Mikako Takatsuka
article en
1 citations

Abstract

This study revealed that most severe AEs, such as anaphylaxis and toxic cutaneous diseases, caused by H1 antihistamines occurred within 1 week of treatment. Hepatotoxicity, alopecia, interstitial pneumonia, and aplastic anemia occurred throughout the treatment period.

International Journal of Clinical Pharmacology and TherapeuticsVol. 63(07)
Good health and well-being
Openalex Percentile: Top 21%
Drug-Induced Adverse Reactions
1.39
DOISourceOpenAlex
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H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database — Tsuyoshi Shiga, Masayuki Hashiguchi, et al. · International Journal of Clinical Pharmacology and Therapeutics (2025) | TGRS Research Map | TGRS