FTY720 Modulating Microglia-Mediated Cholesterol Recycling via TREM2 Promotes Remyelination Following Ischemic Damage
Our study suggested that FTY720 regulated the recycling of myelin-derived cholesterol from microglia through TREM2, supplying cholesterol to oligodendrocytes and supporting remyelination, thus offering a novel therapeutic target for ischemic white matter damage.
Authors
- Xiu‐Lan Sun (ORCID: https://orcid.org/0000-0001-8741-3833)
- Ye-Fan Chen
- Xuejun Ren (ORCID: https://orcid.org/0000-0002-7908-5662)
- Xiyue Zhang (ORCID: https://orcid.org/0000-0003-4544-6893)
- Jian-Bing Yu
- Juan Ji (ORCID: https://orcid.org/0000-0003-4154-1674)
- Chen Hong (ORCID: https://orcid.org/0009-0002-6738-2931)
- Wei Guo (ORCID: https://orcid.org/0009-0009-2564-3348)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1161/strokeaha.124.049745
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.90