Radiation Therapy for the Management of Refractory Giant Condyloma Acuminata: A Case Report

Abstract Giant condyloma acuminata (GCA), also known as Buschke-Löwenstein tumor, is a rare human papillomavirus-related lesion that can affect the anorectal region and is characterized by aggressive local growth and a high recurrence rate. This case report details a 46-year-old immunocompetent man with refractory anorectal GCA that recurred despite multiple surgical interventions, including abdominoperineal resection (APR). Due to the extensive and refractory nature of the recurrent disease following APR, definitive radiation therapy was offered. Intensity-modulated radiation therapy to 50 Gy in 25 fractions resulted in rapid disease regression, symptom relief, and a complete clinical and metabolic response. This case highlights the efficacy of radiation therapy in managing challenging GCA cases.