Sexual dimorphism in metabolomic and phenotypic spectra of UGT deficiency: findings from the Canadian Longitudinal Study on Aging
The findings significantly advance our understanding of the metabolic landscape associated with these frequently deleted genes in the human genome, which may influence susceptibility to various diseases in a sex-specific manner, laying the groundwork for determining their pathological mechanisms and impact on human health.
Authors
- David Simonyan (ORCID: https://orcid.org/0000-0001-8826-7428)
- Ana Lucía Rivera-Herrera
- Tania Cuppens (ORCID: https://orcid.org/0000-0002-7121-0107)
- Narcisse Singbo (ORCID: https://orcid.org/0000-0002-5009-2420)
- Michèle Rouleau (ORCID: https://orcid.org/0000-0002-2357-1848)
- Arnaud Droit (ORCID: https://orcid.org/0000-0001-7922-790X)
- Julien Prunier (ORCID: https://orcid.org/0000-0002-4839-3857)
- Chantal Guillemette (ORCID: https://orcid.org/0000-0002-1113-1212)
Institutions
- Centre hospitalier universitaire de Québec (CA)
- Centre hospitalier de l'Université Laval (CA)
- Université Laval (CA)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s13293-025-00708-5
- Citations
- 2
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Canada Foundation for Innovation
- Canada Research Chairs
- Canadian Institutes of Health Research