Genomic instability is associated with response to [¹⁷⁷Lu]Lu-PSMA-I&T radioligand therapy: an exploratory, preliminary liquid biopsy analysis
Unresponsive patients exhibited higher levels of cfDNA genomic instability and ctDNA levels, warranting genome-wide CNV profiling studies next to targeted approaches for mechanistic radiobiological insights and their value as response biomarkers for PSMA RLTs.
Authors
- Alexander Haug (ORCID: https://orcid.org/0000-0002-8308-6174)
- Kilian Kluge (ORCID: https://orcid.org/0000-0002-4224-7314)
- Lukas Kenner (ORCID: https://orcid.org/0000-0003-2184-1338)
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Gero Kramer (ORCID: https://orcid.org/0000-0003-1982-6817)
- Shahrokh François Shariat (ORCID: https://orcid.org/0000-0002-6627-6179)
- Katarina Kumpf
- David Haberl
Institutions
- University of Jordan (JO)
- Statistics Austria (AT)
- Cornell University (US)
- Charles University (CZ)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- Universitätsklinikum Krems (AT)
- Karl Landsteiner Society (AT)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s00259-025-07280-5
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
- Medizinische Universität Wien
- Christian Doppler Forschungsgesellschaft
- Central European Institute of Technology
- Masarykova Univerzita
- Siemens Healthineers
- Bundesministerium für Digitalisierung und Wirtschaftsstandort