Application of Neoadjuvant Docetaxel plus Cisplatin in Early-Stage Triple-Negative Breast Cancer (HELEN-001): Results from a Phase II Trial
The TP regimen demonstrated significantly improved pCR rates with a manageable toxicity profile, suggesting the potential benefit of taxane plus platinum regimens in patients with TNBC.
Authors
- Lianfang Li
- Xiuchun Chen (ORCID: https://orcid.org/0000-0002-7134-7170)
- Armando Orlandi (ORCID: https://orcid.org/0000-0001-5253-4678)
- Chongjian Zhang
- Fernando Hernánz (ORCID: https://orcid.org/0000-0002-3101-067X)
- Xinlan Liu (ORCID: https://orcid.org/0000-0001-5241-115X)
- Haiquan Jia
- Qingxin Xia (ORCID: https://orcid.org/0000-0003-0216-9179)
- Naohiro Ishii (ORCID: https://orcid.org/0000-0001-8838-5344)
- Xianfu Sun (ORCID: https://orcid.org/0000-0002-6512-080X)
- Min Yan (ORCID: https://orcid.org/0000-0002-3911-748X)
- Chengzheng Wang (ORCID: https://orcid.org/0009-0002-9374-4270)
- Geok Hoon Lim (ORCID: https://orcid.org/0000-0002-5296-3437)
- Zhenzhen Liu (ORCID: https://orcid.org/0000-0002-3878-1258)
- Jianghua Qiao (ORCID: https://orcid.org/0000-0002-3858-4668)
- Yueqing Feng
- Dechuang Jiao (ORCID: https://orcid.org/0009-0003-7441-9103)
- Yong Zhou
- Miao Deng (ORCID: https://orcid.org/0009-0000-9980-3572)
- Zhenduo Lu
- Mingde Ma
Institutions
- Universidad de Cantabria (ES)
- Henan University of Science and Technology (CN)
- Agostino Gemelli University Polyclinic (IT)
- Zhengzhou University (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Marqués de Valdecilla University Hospital (ES)
- KK Women's and Children's Hospital (SG)
- Duke-NUS Medical School (SG)
- Ningxia Medical University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Ningxia Medical University General Hospital (CN)
- Henan Cancer Hospital (CN)
- Xinxiang Central Hospital (CN)
- Anyang Tumor Hospital (CN)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0289
- Citations
- 2
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.87