Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway
Evobrutinib inhibits the expression and activation of BTK in microglia, reducing M1 microglia-mediated neuroinflammation and alleviating ischemic injury following stroke. This effect is mechanistically linked to the inhibition of TLR4/Myd88/NF-κB-mediated M1 polarization of microglia.
Authors
- Xijun Liu (ORCID: https://orcid.org/0000-0002-7219-5914)
- Hulun Li (ORCID: https://orcid.org/0000-0003-2501-6861)
- Xiujuan Lang (ORCID: https://orcid.org/0009-0007-1790-0266)
- Bo Sun (ORCID: https://orcid.org/0000-0001-7001-8781)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7004-2247)
- Ning Wang (ORCID: https://orcid.org/0000-0003-4891-6838)
- Jiayi Li (ORCID: https://orcid.org/0009-0006-6523-1952)
- Yumei Liu (ORCID: https://orcid.org/0000-0002-9702-9779)
- Jinyi Liu (ORCID: https://orcid.org/0000-0003-1803-7752)
- Wei Huang (ORCID: https://orcid.org/0000-0003-1216-5884)
- Yixiang Jiang (ORCID: https://orcid.org/0000-0001-5690-2116)
- Zhengyi Chen (ORCID: https://orcid.org/0000-0003-4774-945X)
- Changxin Yang (ORCID: https://orcid.org/0009-0007-6059-0793)
- Lulu Chang (ORCID: https://orcid.org/0000-0003-2208-6450)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s10020-025-01203-8
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.11
Funders
- National Natural Science Foundation of China