Autoimmune Hemolytic Anemia in 62 Year Old Lady with Mixed Connective Tissue Disorder with Subclinical Hypothyroidism: A Rare Presentation

Mixed connective tissue disease (MCTD) is an overlap syndrome characterized by the presence of U1RNP antibody with features of polymyositis, scleroderma, and systemic lupus erythematosus. A female 62-year-old patient presented with generalized body weakness since 4 months and shortness of breath for 3 months. The patient had a history of repeated blood transfusions, in view of a clinical history of recurrent blood transfusion with hypothyroidism (anti-TPO positive) with direct coomb test positive with ANA positive. She is a case of autoimmune hemolytic anemia. ANA immunoblot shows U1RNP positive, suggestive of mixed connective tissue disorder. She responded well with prednisolone (1-mg/kg) with a tapering dose.