Hypothyreoïdie en statine-geïnduceerde rhabdomyolyse: case report en literatuurstudie

Hypothyroidism and statin-induced rhabdomyolysis: case report and literature review Introduction: Rhabdomyolysis is a serious medical condition caused by the breakdown of skeletal muscle cells, with acute kidney injury as its main complication. A well-known cause is the use of lipid-lowering drugs as statins. However, the predisposing factors for developing rhabdomyolysis with these medications have not been sufficiently investigated. Methods: We present a case of a 64-year-old woman who developed rhabdomyolysis and acute kidney injury three months after initiating treatment with a lipid-lowering drug. We describe the risk factors for statin-induced rhabdomyolysis and conduct a literature review to explore the role of hypothyroidism in this context. Results: After an extensive literature review, fifteen case reports were identified. Among these papers, only three described the association between rhabdomyolysis-induced kidney injury and subclinical hypothyroidism; the remaining cases were associated with either overt or unspecified hypothyroidism. Conclusion: The risk profile for statin-induced rhabdomyolysis is influenced by multiple factors, both static and dynamic. Based on the available literature, we can acknowledge an association between statin-induced rhabdomyolysis and overt hypothyroidism. In the case of subclinical hypothyroidism, this association is unclear. Therefore, based on current data, there is insufficient evidence to recommend routine screening for thyroid dysfunction before initiating statin therapy. However, we do advocate a thorough evaluation of risk factors to reduce the likelihood of muscle toxicity.