Genomic alterations in normal breast tissues preceding breast cancer diagnosis
Individuals who develop breast cancer have a higher germline variant burden in normal breast tissues leading to subtle deficiencies in DNA repair that in the context of other germline and somatic mutations could facilitate malignant transformation.
Authors
- Lajos Pusztai (ORCID: https://orcid.org/0000-0001-9632-6686)
- Shrikant Mane (ORCID: https://orcid.org/0000-0002-3267-5139)
- Mariya Rozenblit
- Xiaoyue Judy Li (ORCID: https://orcid.org/0000-0003-4699-8032)
- Michał Marczyk (ORCID: https://orcid.org/0000-0003-2508-5736)
- Naing Lin Shan (ORCID: https://orcid.org/0000-0002-8572-1311)
- Yueyue Wang (ORCID: https://orcid.org/0000-0002-6018-5380)
- Jiawei Dai (ORCID: https://orcid.org/0000-0003-3806-5160)
Institutions
- Silesian University of Technology (PL)
- Yale Cancer Center (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s13058-025-02018-5
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Breast Cancer Research Foundation
- Narodowym Centrum Nauki