Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats
The finding that SGLT2 inhibition leads to expansion of the S3 segment of the proximal tubule, the site of SGLT1, is suggestive of a physiological response to diminish urinary glucose loss akin to that occurring in experimental diabetes. These findings provide a cogent explanation for the less-thanthan-expected effect of this drug class on glucose reabsorption.
Authors
- Darren A. Yuen (ORCID: https://orcid.org/0000-0002-0054-6607)
- Paraish S. Misra (ORCID: https://orcid.org/0000-0002-0514-8560)
- Caterina Di Ciano‐Oliveira
- Nuno R. Coelho (ORCID: https://orcid.org/0000-0001-6013-5204)
- Kim A. Connelly (ORCID: https://orcid.org/0000-0002-1031-3137)
- Suzanne L. Advani
- Xinglin Wu (ORCID: https://orcid.org/0000-0003-3742-2074)
- Linda Nghiem
- Hai Wang (ORCID: https://orcid.org/0000-0001-5911-4131)
- Richard E. Gilbert (ORCID: https://orcid.org/0000-0002-6858-823X)
- Kerri Thai
- Jean‐François Desjardins
- J. R. Nyengaard
- Sarah Macklin
- Yanling Zhang (ORCID: https://orcid.org/0000-0001-6381-1765)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1111/jdi.70043
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- AstraZeneca
- Canada Research Chairs
- University of Toronto
- Department of Medicine, University of Toronto