Incident Stroke in Pediatric Sickle Cell Anemia Despite Overall Improved Transcranial Doppler Velocity in a Ugandan Hydroxyurea Trial: Antecedent and Ongoing Risks
The effectiveness of TCD screening for stroke prevention may vary by region, as no participant with an incident stroke was at the highest risk. Antecedent and/or ongoing SCA-related risks of anemia, low HbF, hypoxemia, infections, and/or disease complications likely contributed to stroke despite trial HU. Results suggest that TCD alone may not fully identify the highest stroke risk in the region, and there is a need for primary stroke prevention from early childhood and continuous hydroxyurea therapy.
Authors
- Phillip Kasirye (ORCID: https://orcid.org/0000-0001-6620-483X)
- Dennis M. Kalibbala (ORCID: https://orcid.org/0000-0002-5003-0414)
- Nancy Green (ORCID: https://orcid.org/0000-0002-9877-1561)
- Ruth Namazzi (ORCID: https://orcid.org/0000-0003-2459-6526)
- Richard Idro
- Susan Murungi
- Amiirah Mpungu
- Deogratias Munube (ORCID: https://orcid.org/0000-0002-1312-6804)
- Maria Nakafeero (ORCID: https://orcid.org/0000-0002-8133-3223)
- Vincent Mboizi
- Maxencia Kabatabaazi
- Grace Nambatya
- Bill Wambaka
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Columbia University Irving Medical Center (US)
- World Health Organization - Uganda (UG)
- Makerere University (UG)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1002/pbc.31722
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63