Toward comprehending uncommon periocular manifestations: A case of localized AL amyloidosis with a rare spontaneous eyelid ecchymosis
IntroductionAmyloidosis, characterized by extracellular protein misfolding and deposition. Localized immunoglobulin light chain amyloidosis can present with atypical features.Case presentationThis case report elucidates an unconventional manifestation of localized immunoglobulin light chain amyloidosis characterized by recurrent and spontaneous eyelid ecchymosis alternating with episodes of incomplete resolution, a novelty in current literature, along with associated cutaneous changes.DiscussionThis rare presentation underscores the importance of considering amyloidosis in the differential diagnosis of unusual periocular findings and may assist in identifying similar cases of atypical eyelid amyloidosis, especially in cases with limited involvement, promoting early diagnosis and intervention.
Authors
- Bárbara Flores Culau Merlo (ORCID: https://orcid.org/0000-0003-4049-5784)
- Márcio Penha Morterá Rodrigues (ORCID: https://orcid.org/0000-0003-2771-1542)
- Denize D’Azambuja Ramos
- Tullia Cuzzi Teichner
- Danielle Carvalho Quintella (ORCID: https://orcid.org/0000-0001-9013-9417)
- Caio Brenno Abreu (ORCID: https://orcid.org/0000-0002-5607-6237)
- Fernanda Simões Dourado (ORCID: https://orcid.org/0000-0003-0888-6849)
- Juliana de Sá Freire Medrado Dias
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Hospital Universitário Clementino Fraga Filho (BR)
Publication Details
- Journal
- European Journal of Ophthalmology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1177/11206721251333603
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00