ADAGIO: A Phase IIb, Open-Label, Single-Arm, Multicenter Study Assessing the Efficacy and Safety of Adavosertib (AZD1775) as Treatment for Recurrent or Persistent Uterine Serous Carcinoma
Adavosertib showed some antitumor activity in patients with recurrent/persistent USC. However, at 300 mg once daily dosing, it was not well tolerated in this population. Exploratory biomarker studies suggest <i>CCNE1</i>/cyclin E1 expression may enrich for response to Wee1 inhibition in USC.
Authors
- Sarah Chiang (ORCID: https://orcid.org/0000-0001-9698-0936)
- Lydia Gaba (ORCID: https://orcid.org/0000-0002-6898-0557)
- Maria M. Rubinstein (ORCID: https://orcid.org/0000-0002-7943-8245)
- Didier Meulendijks (ORCID: https://orcid.org/0000-0002-4580-426X)
- Stéphanie Lheureux (ORCID: https://orcid.org/0000-0003-4405-5890)
- Lucía González Cortijo (ORCID: https://orcid.org/0000-0003-2082-670X)
- Jean‐Sébastien Frenel (ORCID: https://orcid.org/0000-0002-5273-0561)
- Bradley R. Corr (ORCID: https://orcid.org/0000-0002-6608-2585)
- Vanda Salutari (ORCID: https://orcid.org/0009-0007-1104-7866)
- Nicole Nevadunsky (ORCID: https://orcid.org/0000-0001-5680-0670)
- Mark J. O’Connor (ORCID: https://orcid.org/0000-0003-1823-625X)
- Joyce F. Liu (ORCID: https://orcid.org/0000-0003-3888-3972)
- Ana Oaknin (ORCID: https://orcid.org/0000-0002-3592-7194)
- Amit M. Oza (ORCID: https://orcid.org/0000-0002-9510-8641)
- Benoît You (ORCID: https://orcid.org/0000-0002-3177-8857)
- Dana Ghiorghiu
- Nicoletta Colombo (ORCID: https://orcid.org/0000-0003-2225-715X)
- Mahmuda Khatun
- Lenka Oplustil O'Connor
Institutions
- AstraZeneca (United Kingdom) (GB)
- University Health Network (CA)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- University of Toronto (CA)
- Agostino Gemelli University Polyclinic (IT)
- Princess Margaret Cancer Centre (CA)
- Hospices Civils de Lyon (FR)
- Institut de Cancérologie de l'Ouest (FR)
- Hospital Universitario Quirónsalud Madrid (ES)
- Dana-Farber Cancer Institute (US)
- Vall d'Hebron Hospital Universitari (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Vall d'Hebron Institute of Oncology (ES)
- University of Colorado Anschutz Medical Campus (US)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- Universitat de Barcelona (ES)
- Nantes Université (FR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1200/jco-24-01606
- Citations
- 7
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 11.89