FKBP5 Platelet Gene Expression in Acute Coronary syndrome

Objectives: To evaluate platelet gene FKBP5 is expressed in patient with Acute coronary syndrome (ACS) in comparison to healthy participants. Background :ACS is one of the top causes of mortality across the world, particularly myocardial infarction (MI). Data collected from previous study identified five differentially expressed platelet genes: (FKBP5, SAMSN1,S100P, S100A12andCLEC4E) at the time of acute MI, and FKBP5showed the greatest evidence of differential expression. Methods: Thiscross sectionalprospective study was performed on 90 cases divided into two main groups: healthy participant group (30) and ACS group (60) that further subdivided into ST-elevation MI(STEMI) group (30) and unstable angina (UA) group (30) who underwent percutaneous coronary intervention and polymerase chain reaction. Results: FKBP5 platelet gene expression can predict patients with ACS at the cutoff point > 3.04 with specificity of 90.0%, sensitivity of 70.0%, area under curve (AUC) of 0.800 and was significantlyelevated in (ACS group) in comparison to (HP group), with (P3.04. Only FKBP5 gene expression (VQ) >3.04, is more accurate in ACS event prediction compared to predictive parameters with (p