Use of Nutraceutical in Leukemia

Leukemia, a heterogeneous group of hematological malignancies, remains a major clinical challenge despite advancements in chemotherapeutic and targeted approaches. Conventional treatments are often associated with significant side effects and drug resistance, necessitating the exploration of alternative or complementary therapies. Nutraceuticals—naturally derived bioactive compounds found in foods and medicinal plants—have gained attention for their potential anti-leukemic properties. These compounds, including curcumin, resveratrol, quercetin, and epigallocatechin gallate, exhibit antiinflammatory, antioxidant, pro-apoptotic, and anti-proliferative effects through modulation of critical signaling pathways implicated in leukemia pathogenesis. This review provides a comprehensive analysis of various nutraceuticals studied in the context of leukemia, summarizing their mechanisms of action, preclinical and clinical evidence, and therapeutic potential. Additionally, challenges such as bioavailability, safety, and regulatory concerns are discussed, along with future directions including nanocarrier-based delivery and personalized therapy. The integration of nutraceuticals into leukemia management holds promise, but requires further validation through rigorous scientific and clinical research.