The role of scavenger receptors on macrophages of the greater omentum in serous borderline ovarian tumors

The paper presents an immunohistochemical study of greater omenta in serous borderline ovarian tumors. The role of scavenger receptors in the cells of the greater omentum in this pathology has not been sufficiently studied. Theat is why, this work is of scientific interest, and the topic under study is relevant. The purpose of the study is to analyze the expression level of scavenger receptors on macrophages in the greater omentum in serous borderline ovarian tumors. Materials and methods. The study determined the expression of scavenger receptors by immunohistochemical methods on macrophages of the greater omentum in 40 patients. The entry criteria were the presence of serous borderline ovarian tumors in the patients, surgical treatment for borderline ovarian tumors with omentectomy, as well as the age of the patients from 20 to 45 years. The exclusion criteria were severe concomitant diseases in patients. The expression of scavenger receptors on macrophages of the greater omentum was evaluated. Markers of macrophages CD91 (SR-L1), CD204 (SR-A1), CD68 (SR-D1) were studied: antibodies to macrophage markers CD91, CD204, CD68 were used. A morphometric study of the preparations was conducted. The STATISTICA 10 program (StatSoft) was used for statistical processing of the results obtained. Research results. In the study of greater omentum preparations in serous borderline ovarian tumors, when assessing the level of CD91 (SR-L1) expression, it was shown that in serous borderline tumors without implantation damage, the average CD91 expression score was lower than that in serous borderline tumors with implantation damage. The analysis of CD204 (SR-A1) expression in the greater omentum demonstrated that in serous borderline tumors without implantation lesion, the average CD204 expression score was lower than that in serous borderline tumors with implantation lesion. When assessing the expression level of CD68 (SR-D1) in the greater omentum, it was found that in serous borderline tumors without implantation lesion, the average CD68 expression score was lower compared with a serous borderline tumors with implantation lesion. Conclusions. The greater omentum participates in implementing immune reactions due to the population of macrophages expressing scavenger receptors. These cells trigger the initiation of antitumor immunity by increasing the number of CD68+, CD91+, CD204+ and have the ability to inhibit the formation of tumors dissemination.