Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database
CDAI reduction is an independent risk factor for both PD risk in the general population and all-cause mortality in PD patients, with amplified predictive power in older adults, smokers, and hypertensive individuals. Our findings support developing personalized antioxidant-enhancing nutritional interventions for both high-risk populations with suboptimal CDAI and established PD patients.
Authors
- Dan He (ORCID: https://orcid.org/0000-0002-0288-0529)
- Chanjuan Chen (ORCID: https://orcid.org/0000-0002-9853-2632)
- Jingwen Hao (ORCID: https://orcid.org/0000-0002-2747-4826)
- Qun Liu (ORCID: https://orcid.org/0000-0003-0991-8144)
- Fei Huang (ORCID: https://orcid.org/0000-0003-3841-9192)
Institutions
- The First Hospital of Changsha (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fnagi.2025.1510654
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hunan Province