7,8-Dihydroxyflavone provides neuroprotection and rescues behavioral deficits in Angiostrongylus cantonensis-infected mice by ameliorating synaptic loss
These findings suggested that 7,8-DHF could confer neuroprotective effects, particularly in mitigating synaptic loss in the presynaptic region, and alleviating behavioral deficits from infection without inducing cell death. We anticipate these results will aid in the treatment of angiostrongyliasis-induced neurological damage.
Authors
- Kai-Yuan Jhan
- Kuang-Yao Chen (ORCID: https://orcid.org/0000-0002-9783-3775)
- Lian-Chen Wang (ORCID: https://orcid.org/0000-0002-6862-2215)
- Cheng‐Hsun Chiu (ORCID: https://orcid.org/0000-0003-4324-7743)
- Pi-Kai Chang (ORCID: https://orcid.org/0000-0002-9308-5298)
- Chih-Jen Chou
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jmii.2025.04.001
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Chang Gung Memorial Hospital
- Ministry of Science and Technology, Taiwan