Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation
Taken together, our findings suggest that in LPS-induced systemic inflammation, <i>Tnf-α</i> and <i>Il1β</i> drive region-specific neurodegeneration via apoptotic processes, while <i>Il6</i> and its regulatory interaction with neurotrophins may serve as a protective mechanism in neuroinflammation.
Authors
- Sooraj Baijnath (ORCID: https://orcid.org/0000-0001-7860-1779)
- Leandrie Pienaar (ORCID: https://orcid.org/0000-0002-8309-297X)
- Aletta ME. Millen
- Adalayne Ramsamy
Institutions
- University of the Witwatersrand (ZA)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100515
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37