Utility of tumor and non-tumor biopsies during percutaneous radiofrequency ablation for hepatocellular carcinoma
Tumor and non-tumor biopsies during radiofrequency ablation for hepatocellular carcinoma are both safe and feasible, with a low complication rate and no procedure-related deaths. We demonstrated the diagnostic utility of biopsies, revealing discrepancies in 5% of cases between tumor board and histological results, which could refine patient management strategies. We identified significant associations between hepatocellular carcinoma subtypes and recurrence rates, and found that molecular analysis based on frozen tumor samples is feasible in most cases and could be guided by the percentage of tumors cells on paraffin-embedded samples.
Authors
- Olivier Sutter (ORCID: https://orcid.org/0000-0002-2802-9652)
- Marianne Ziol (ORCID: https://orcid.org/0000-0001-5117-4842)
- Jean‐Charles Nault (ORCID: https://orcid.org/0000-0002-4875-9353)
- G. Nkontchou (ORCID: https://orcid.org/0000-0003-4697-2086)
- Alix Demory
- Lorraine Blaise (ORCID: https://orcid.org/0000-0001-5344-1625)
- Lucie Del Pozo
- Claudia Campani (ORCID: https://orcid.org/0000-0003-3842-782X)
- Olivier Séror (ORCID: https://orcid.org/0000-0001-6680-8991)
- Jessica Zucman‐Rossi (ORCID: https://orcid.org/0000-0002-5687-0334)
- Pierre Nahon (ORCID: https://orcid.org/0000-0003-2489-0768)
- Elvire Desjonqueres
- Nathalie Ganne‐Carrié (ORCID: https://orcid.org/0000-0002-7351-5027)
- Lorenzo Pescatori (ORCID: https://orcid.org/0000-0001-8055-4801)
- Nathalie Barget
- Carina Boros
- Véronique Grando
Institutions
- Inserm (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Association pour la Recherche en Physiologie de l’Environnement (FR)
- Hôpital Avicenne (FR)
- University of Florence (IT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101430
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64