Aberrant Aversive Learning Signals in the Habenula in Remitted Patients With Recurrent Depression
The increased habenula activity during aversive learning, particularly during the expectation of punishment, together with decreased functional habenula-ventral tegmental area connectivity in remitted patients with MDD, reflect hypersensitivity to and/or inability to regulate the impact of aversive environmental cues and punishment.
Authors
- Roel J. T. Mocking (ORCID: https://orcid.org/0000-0003-3543-3810)
- Hanneke Geugies
- Jessica M. de Klerk‐Sluis (ORCID: https://orcid.org/0000-0001-9504-5030)
- Philip van Eijndhoven (ORCID: https://orcid.org/0000-0003-3474-4326)
- P.F.C. Groot (ORCID: https://orcid.org/0000-0001-5788-8627)
- Caroline Figueroa (ORCID: https://orcid.org/0000-0003-0692-2244)
- Dirk E. M. Geurts (ORCID: https://orcid.org/0000-0002-2505-1301)
- Jan-Bernard C. Marsman
- Henricus G. Ruhé (ORCID: https://orcid.org/0000-0001-6072-0358)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Martini Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.bpsc.2025.04.006
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- European College of Neuropsychopharmacology
- H. Lundbeck A/S