Efficacy of atezolizumab plus bevacizumab for unresectable HCC: Systematic review and meta-analysis of real-world evidence
This study provides real-world evidence supporting the long-term efficacy of atezolizumab plus bevacizumab (A+B) for unresectable hepatocellular carcinoma, showing survival outcomes similar to those achieved in clinical trials. These findings are important for clinicians in supporting A+B as a frontline treatment, particularly for patients with Child-Pugh class A liver function. They also offer valuable insights for policymakers and researchers for optimising treatment strategies for unresectable hepatocellular carcinoma. However, results should be interpreted with caution because of potential variability in patient populations.
Authors
- David James Pinato (ORCID: https://orcid.org/0000-0002-3529-0103)
- Calogero Cammà (ORCID: https://orcid.org/0000-0002-9224-1914)
- Amit G. Singal (ORCID: https://orcid.org/0000-0002-1172-3971)
- Pei-Chang Lee
- Antonio D’Alessio (ORCID: https://orcid.org/0000-0002-9164-3671)
- Ciro Celsa (ORCID: https://orcid.org/0000-0002-5662-2162)
- Charles Latchford
- Giuseppe Cabibbo (ORCID: https://orcid.org/0000-0002-0946-3859)
- Chung‐Yen Lin (ORCID: https://orcid.org/0000-0002-4733-9488)
- Fabio Piscaglia (ORCID: https://orcid.org/0000-0001-8264-1845)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Pasquale Lombardi (ORCID: https://orcid.org/0000-0001-6262-2161)
- Leonardo Brunetti (ORCID: https://orcid.org/0000-0003-2639-4135)
- Anjana Pillai (ORCID: https://orcid.org/0000-0001-6783-2109)
- Matthias Pinter (ORCID: https://orcid.org/0000-0002-7260-532X)
- Lorenza Rimassa (ORCID: https://orcid.org/0000-0001-9957-3615)
- Giulia Francesca Manfredi (ORCID: https://orcid.org/0000-0002-2399-5376)
- Hong Jae Chon (ORCID: https://orcid.org/0000-0002-6979-5812)
- Yi‐Hsiang Huang (ORCID: https://orcid.org/0000-0001-5241-5425)
- Mario Pirisi (ORCID: https://orcid.org/0000-0001-9740-0155)
- Bernardo Stefanini (ORCID: https://orcid.org/0000-0003-3800-5678)
- Arndt Vogel (ORCID: https://orcid.org/0000-0003-0560-5538)
- Andrea Dalbeni (ORCID: https://orcid.org/0000-0003-0402-4176)
- Nichola Awosika
- Peter R. Galle (ORCID: https://orcid.org/0000-0003-1967-0621)
- Claudia Angela Maria Fulgenzi
- B Scheiner
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Verona (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Humanitas University (IT)
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- Johannes Gutenberg University Mainz (DE)
- Hammersmith Hospital (GB)
- Agostino Gemelli University Polyclinic (IT)
- Princess Margaret Cancer Centre (CA)
- Taipei Veterans General Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- Medizinische Hochschule Hannover (DE)
- University of Chicago (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Southwestern Medical Center (US)
- Azienda USL di Bologna (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- CHA University Bundang Medical Center (KR)
- CHA University (KR)
- IRCCS Humanitas Research Hospital (IT)
- Southwestern Medical Center (US)
- Imperial College London (GB)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
- University of Palermo (IT)
- Kindai University (JP)
- University of Bologna (IT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101431
- Citations
- 5
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.23