EXPRESSION OF CONCERN: Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild‐type and Swedish mutated β‐amyloid precursor protein

A third party reported to the journal that the A 40 (A 42) panel in Figure 4A had been duplicated in Figure 5A and that the last two gel panels of APP in Figure 4B appear to have been duplicated in Figure 5B.An investigation by the publisher and journal confirmed this report and that both sets of data are presented as having different experimental conditions.The authors responded to an inquiry by the publisher and stated that the APP images are the same, but that these cells were treated with two different inhibitors in Figures 4B and5B and that each had different A 42 expressions.The authors stated that the original data are not available due to the considerable time since publication.

Publication Details

Journal
British Journal of Pharmacology
Published
2025-04-22
DOI
https://doi.org/10.1111/bph.70068
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
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article

EXPRESSION OF CONCERN: Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild‐type and Swedish mutated β‐amyloid precursor protein

British Journal of Pharmacology
Peptidase Inhibition and Analysis
article

EXPRESSION OF CONCERN: Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild‐type and Swedish mutated β‐amyloid precursor protein

article en

Abstract

A third party reported to the journal that the A 40 (A 42) panel in Figure 4A had been duplicated in Figure 5A and that the last two gel panels of APP in Figure 4B appear to have been duplicated in Figure 5B.An investigation by the publisher and journal confirmed this report and that both sets of data are presented as having different experimental conditions.The authors responded to an inquiry by the publisher and stated that the APP images are the same, but that these cells were treated with two different inhibitors in Figures 4B and5B and that each had different A 42 expressions.The authors stated that the original data are not available due to the considerable time since publication.

British Journal of PharmacologyVol. 182(12)
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Peptidase Inhibition and Analysis
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