Longitudinal dynamics of the nasopharyngeal microbiome in response to SARS-CoV-2 Omicron variant and HIV infection in Kenyan women and their children
The nasopharyngeal microbiome plays an important role in human health. The degree of impact that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has on the nasopharyngeal microbiome varies among studies and may be influenced by diverse SARS-CoV-2 variants and variations in the microbiome between individuals. Our results show that the nasopharyngeal microbiome was not altered substantially by SARS-CoV-2 infection nor by HIV infection in mothers or HIV exposure in children. Our findings highlight the resilience of the nasopharyngeal microbiome after SARS-CoV-2 infection. These findings advance our understanding of the nasopharyngeal microbiome and its interactions with viral infections.
Authors
- Dalton C. Wamalwa (ORCID: https://orcid.org/0000-0002-5510-462X)
- Ednah Ojee (ORCID: https://orcid.org/0000-0001-9730-5254)
- Lily I. Wu
- Soren M. Gantt (ORCID: https://orcid.org/0000-0001-5743-3606)
- Efrem S. Lim (ORCID: https://orcid.org/0000-0002-3397-9310)
- LaRinda A. Holland
- John Kinuthia (ORCID: https://orcid.org/0000-0001-6571-8927)
- Jennifer A. Slyker (ORCID: https://orcid.org/0000-0001-7095-8861)
- Steven C. Holland (ORCID: https://orcid.org/0000-0003-0649-3611)
- Tianchen Mu
- Emily R. Begnel (ORCID: https://orcid.org/0000-0003-3491-7303)
- Bhavna Chohan (ORCID: https://orcid.org/0000-0002-2125-6799)
- Dara A. Lehman (ORCID: https://orcid.org/0000-0002-0372-0631)
- Barbra A. Richardson (ORCID: https://orcid.org/0000-0001-9564-1828)
- James C. Hu (ORCID: https://orcid.org/0000-0001-9016-2684)
- Victoria R. Leonard
- Ayla Žuštra
Institutions
- University of Nairobi (KE)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Washington (US)
- Kenyatta National Hospital (KE)
- Kenya Medical Research Institute (KE)
- Fred Hutch Cancer Center (US)
- Cancer Research Center (US)
- National Centre for Infectious Diseases (SG)
- Arizona State University (US)
- Université de Montréal (CA)
Publication Details
- Journal
- mSystems
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1128/msystems.01568-24
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- Canadian Institutes of Health Research