Emergence of KPC-8-producing <i>K. pneumoniae</i> infection without prior exposure to ceftazidime/avibactam: the threat of <i>de novo</i> infections by ceftazidime/avibactam-resistant KPC variants

<i>De novo</i> infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing <i>Klebsiella pneumoniae</i> strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant <i>Escherichia coli</i> isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.

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Publication Details

Journal
Antimicrobial Agents and Chemotherapy
Published
2025-04-22
DOI
https://doi.org/10.1128/aac.01494-24
Citations
2
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
1.18

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article

Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

María Alejandra Mateo-Vargas, Salud Rodríguez-Pallares, Fátima Galán‐Sánchez, Manuel Rodríguez‐Iglesias et al.
2 citations
Antimicrobial Agents and Chemotherapy
Antibiotic Resistance in Bacteria
1.18
article

Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

María Alejandra Mateo-Vargas, Salud Rodríguez-Pallares, Fátima Galán‐Sánchez, Manuel Rodríguez‐Iglesias, Jorge Arca-Suárez, Lorena López‐Cerero
article en
2 citations

Abstract

<i>De novo</i> infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing <i>Klebsiella pneumoniae</i> strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant <i>Escherichia coli</i> isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.

Antimicrobial Agents and ChemotherapyVol. 69(6)
Instituto de Salud Carlos III (ES), Universidad de Cádiz (ES), Hospital Universitario Virgen Macarena (ES), Biomedical Research and Innovation Institute of Cadiz (ES), Instituto de Biomedicina de Sevilla (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario Puerta del Mar (ES), Instituto de Investigación Biomédica de A Coruña (ES), Universidad de Sevilla (ES)
Axencia Galega de Innovación, Menarini Group, Instituto de Salud Carlos III
Good health and well-being
Openalex Percentile: Top 23%
Antibiotic Resistance in Bacteria
1.18
DOIOpen Access PDFOpenAlex
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