Morphological, phenotypical and molecular characterization of canine lymphomas with dual T- and B-cell markers expression
The findings emphasize that while immunohistochemistry remains a fundamental diagnostic tool, it may be insufficient in isolation for definitive lineage determination in these cases. PARR analysis emerges as an essential complementary technique for distinguishing between aberrant marker expression and true biphenotypic differentiation.
Authors
- Maria Massaro (ORCID: https://orcid.org/0000-0001-5313-2849)
- Barbara Banco
- Margherita Orlandi (ORCID: https://orcid.org/0000-0001-6787-1300)
- Anna María Rambaldi (ORCID: https://orcid.org/0000-0003-2221-3296)
- Selina Iussich (ORCID: https://orcid.org/0000-0003-0361-131X)
- Michele Marino (ORCID: https://orcid.org/0000-0003-4651-6128)
- Francesca Abramo (ORCID: https://orcid.org/0000-0003-4414-4359)
- F. Arena
- Valeria Martini (ORCID: https://orcid.org/0000-0002-9882-2867)
- Luca Aresu (ORCID: https://orcid.org/0000-0002-7893-1740)
- Luca Pazzini
- Giorgia Mezzalira (ORCID: https://orcid.org/0000-0001-9857-3867)
- Giulio Cocciolo
- Alessandro Bisognoso
Institutions
- University of Pisa (IT)
- University of Milan (IT)
- Valeas (Italy) (IT)
- University of Turin (IT)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fvets.2025.1578425
- Citations
- 1
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52