Opioid Tapering and Opioid Overdose, Opioid Use Disorder, and Mortality Among Older Adults: A Nested Case–Control Study
The results suggest that any opioid dose change for patients on LTOT may negatively affect all-cause mortality. Clinicians should regularly assess patients on LTOT, considering the benefits and risks of treatment that incorporate evolving evidence on dose changes.
Authors
- Prachi Prajapati
- John P. Bentley (ORCID: https://orcid.org/0000-0002-9241-6833)
- Sujith Ramachandran (ORCID: https://orcid.org/0000-0002-8792-4307)
- Kaustuv Bhattacharya (ORCID: https://orcid.org/0000-0001-8857-1817)
- Ike Eriator
- Shishir Maharjan
- Yi Yang (ORCID: https://orcid.org/0000-0003-1575-5257)
- Shadi Bazzazzadehgan (ORCID: https://orcid.org/0000-0002-1407-4727)
Institutions
- University of Mississippi Medical Center (US)
- University of Mississippi (US)
Publication Details
- Journal
- Journal of General Internal Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s11606-025-09492-9
- Citations
- 3
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Institute on Drug Abuse