Bioactive Sesterterpenoids from the Mangrove-Derived <i>Aspergillus</i> sp. GXIMD 03023
Four novel sesterterpenoids, asperterpenoids Q-T (<b>1</b>-<b>4</b>), featuring a rare 5/7/(3)6/5 pentacyclic skeleton were isolated from the mangrove-derived fungus <i>Aspergillus</i> sp. GXIMD 03023 using an NMR-guided approach. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, including 1D/2D-NMR and HRESIMS, supplemented by experimental and ECD spectral matching, DFT-calculated <sup>13</sup>C NMR chemical shifts, and DP4plus probability analysis. Compounds <b>1</b>-<b>4</b> were screened for antibacterial activity and benign prostatic hyperplasia (BPH) inhibitory activity. Compound <b>1</b> showed weak activity against <i>Vibrio harveyi</i> and <i>Xanthomonas campestris</i>, with MIC values of 3.12 and 6.25 μg/mL, respectively. Compound <b>3</b> had significant inhibitory activity against BPH with an IC<sub>50</sub> value of 3.68 μM.
Authors
- Yuman Gan
- Meng Bai (ORCID: https://orcid.org/0000-0002-1024-3458)
- Xiangxi Yi (ORCID: https://orcid.org/0000-0002-8251-8836)
- Chenghai Gao (ORCID: https://orcid.org/0000-0002-7524-8049)
- Kai Liu (ORCID: https://orcid.org/0000-0002-0097-0723)
- Yonghong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
- Jiali He (ORCID: https://orcid.org/0000-0002-4624-4022)
- Yu Wang (ORCID: https://orcid.org/0000-0001-8697-2940)
Institutions
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00182
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Guangxi Traditional Chinese Medical University
- Guangxi Key Research and Development Program