Maternal B12 deficiency during pregnancy dysregulates fatty acid metabolism and induces inflammation in human adipose tissue
Our novel data highlights that B12 deficiency dysregulates lipids and induces inflammation in AT and circulation, which could contribute to adipocyte dysfunction exacerbating cardiometabolic risk during pregnancy.
Authors
- Joseph Boachie
- Philip G. McTernan
- Mark Christian (ORCID: https://orcid.org/0000-0002-1616-4179)
- Jinous Samavat
- Ponnusamy Saravanan (ORCID: https://orcid.org/0000-0002-9566-2626)
- Antonysunil Adaikalakoteswari (ORCID: https://orcid.org/0000-0003-2974-3388)
Institutions
- University of Cape Coast (GH)
- George Eliot Hospital (GB)
- University of Warwick (GB)
- Nottingham Trent University (GB)
- De Montfort University (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12916-025-04056-4
- Citations
- 4
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Nottingham Trent University
- Trent University
- University Hospitals Coventry and Warwickshire NHS Trust
- Medical Research Council