LncRNA MRF targeting FSHR inhibits the osteogenic differentiation of BMSCs and bone defect repair through the regulation of the cAMP-PKA-CREB signaling pathway
MRF modulates the cAMP/PKA/CREB signaling pathway via the follicle stimulating hormone receptor (FSHR), thereby influencing the ossification differentiation of BMSCs. Our research suggests that MRF may serve as a potential target for bone-related disorders.
Authors
- Huatao Liu (ORCID: https://orcid.org/0000-0003-2088-9962)
- Enming Chen (ORCID: https://orcid.org/0000-0001-9816-385X)
- Zhuangyao Liao (ORCID: https://orcid.org/0000-0003-2219-1517)
- Yuanquan Chen
- Yuwei Liang (ORCID: https://orcid.org/0000-0001-8894-0256)
- Min Li (ORCID: https://orcid.org/0000-0002-7113-2700)
- Yuxi Li (ORCID: https://orcid.org/0000-0002-4470-7679)
- Lin Chong Huang (ORCID: https://orcid.org/0000-0002-8285-2658)
- Qing Ning
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13287-025-04291-9
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Natural Science Foundation of Guangdong Province