Preeclampsia beyond pregnancy: investigating the long-term increase in cardiovascular disease and metabolic syndrome (PERLA- Brazil study)

Brazilian Cohort Study of Preeclampsia: latent risks after pregnancy (PERLA-Brazil) are a retrospective cohort study including women with and without preeclampsia history, 6-15 years after pregnancy, aiming to evaluate lipid profile, clinical parameters and the frequency of metabolic syndrome. A total of 188 women from Belo Horizonte (Brazil), who became pregnant between 2008 and 2017, were included: 86 with PE history and 102 with normotensive pregnancy. The participants underwent an interview and had blood samples collected between 2022 and 2023. The following data were collected, using standard equipment and techniques: blood pressure, body weight, height, body fat percentage, waist and hip circumference and lipid profile. For variable comparisons, T-test, Mann-Whitney, and chi-square test were used. A linear regression model assessed the isolated effect of a positive history of PE on cardiovascular risk indicators. PE group had higher body mass index compared to normotensive pregnancy, as well as fat percentage, systolic blood pressure, diastolic blood and low-density lipoprotein. Finally, a higher frequency of metabolic syndrome was detected in PE history group. These results suggested that women who had PE showed a combination of cardiovascular risk markers and increased frequency of metabolic syndrome. To mitigate the risk of subsequent chronic diseases, lifestyle modifications are recommended, along with more frequent follow-ups with a health-care team.