RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response
We identified RBM39 as a regulatory factor of cell intrinsic innate immune signaling. Depletion of RBM39 impaired TLR3, RIG-I/MDA5, and IFN responses by affecting the basal expression of key pathway components.
Authors
- Oliver Grünvogel
- Ralf F. W. Bartenschlager (ORCID: https://orcid.org/0000-0001-5601-9307)
- Santa-Mariela Olivera-Ugarte
- Jeongbin Park
- Nelson Acosta‐Rivero
- Marco Binder (ORCID: https://orcid.org/0000-0002-5805-6109)
- Paul Rothhaar
- Andreas Betz
- Ruiyue Qiu
- Volker Lohmann (ORCID: https://orcid.org/0000-0001-8719-7608)
- Ann-Kathrin Mehnert
- Martina U. Muckenthaler
- Dirk Wohlleber (ORCID: https://orcid.org/0000-0003-3861-5150)
- Andreas Pichlmair (ORCID: https://orcid.org/0000-0002-0166-1367)
- Hao-En Huang
- Jannik Traut
- Matthias Schlesner (ORCID: https://orcid.org/0000-0002-5896-4086)
- Vladimir Gonçalves Magalhães
- Viet Loan Dao Thi (ORCID: https://orcid.org/0000-0003-2293-3592)
- Antonio Piras (ORCID: https://orcid.org/0000-0002-5724-9355)
- Ombretta Colasanti
- Stephan Urban (ORCID: https://orcid.org/0000-0003-1560-8038)
- Gnimah Eva Gnouamozi
- E Springer
- Arthur Lang
- Teng-Feng Li
Institutions
- University of Augsburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Unit of Virus Host Cell Interactions (FR)
- University Hospital Heidelberg (DE)
- TUM Klinikum (DE)
- German Center for Infection Research (DE)
- Convergence (US)
- Institute of Virology of the Slovak Academy of Sciences (SK)
- Pusan National University (KR)
- Technical University of Munich (DE)
- Heidelberg University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1568056
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80