Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers
This study identifies the minimum single dose of RHH from 2.5 units/0.2 ml to 140 units/0.2 ml for dissolution of 22 different hyaluronic acid fillers over 6 hours. These results paired with previous studies help elucidate the dissolution profiles of each filler in the context of their rheological properties, further informing physicians on how to optimally dissolve different hyaluronic acid fillers in a clinical setting.
Authors
- Shreya Gupta (ORCID: https://orcid.org/0000-0003-3783-0617)
- Rasika Sudharshan (ORCID: https://orcid.org/0000-0001-9918-6703)
- Wendy W. Lee (ORCID: https://orcid.org/0000-0001-7624-777X)
- Sandy Zhang-Nunes (ORCID: https://orcid.org/0000-0001-5435-3424)
- Femida Kherani
- Shaili S. Davuluru
- Alena Shen
- Julie A. Woodward
- Jill A. Foster
- Nikta Saeedi
Institutions
- University of British Columbia (CA)
- University of Miami (US)
- University of Calgary (CA)
- Duke University (US)
- Keck Hospital of USC (US)
- Southern California Eye Institute (US)
- Eye Center (SA)
- The Ohio State University (US)
Publication Details
- Journal
- Ophthalmic Plastic and Reconstructive Surgery
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1097/iop.0000000000002941
- Citations
- 2
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.01