Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model
These findings demonstrate that sEH blockade or EET augmentation confers therapeutic benefit in neurodegenerative tauopathies by simultaneously targeting neuronal and microglial pathways.
Authors
- Baijayanti Ghosh
- Chuangye Qi
- Chetan Singh Rajpurohit (ORCID: https://orcid.org/0000-0002-4999-155X)
- Baiping Wang (ORCID: https://orcid.org/0000-0001-7074-2235)
- Hui Zheng (ORCID: https://orcid.org/0000-0002-5427-3798)
- Wen Xiong (ORCID: https://orcid.org/0000-0002-2825-2061)
- Sung Hee Hwang (ORCID: https://orcid.org/0000-0002-9891-928X)
- Yanyan Qi (ORCID: https://orcid.org/0000-0003-0537-1540)
- Li Gan (ORCID: https://orcid.org/0000-0003-4600-275X)
- Shuo Wang (ORCID: https://orcid.org/0000-0001-7462-6178)
- Hongjie Li
- Bruce D. Hammock
Institutions
- Baylor College of Medicine (US)
- Cornell University (US)
- Baylor Genetics (US)
- Weill Cornell Medicine (US)
- UC Davis Comprehensive Cancer Center
- University of California, Davis (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s13024-025-00844-x
- Citations
- 6
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Cure Alzheimer's Fund
- Harrington Discovery Institute, University Hospitals
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke