Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway
In conclusion, sildenafil enhanced hMSC osteogenic differentiation and inhibited bone loss. Sildenafil may usefully treat osteoporosis. Our findings offer new insights into the physiological effects of the medicine.
Authors
- Xinyi Dong
- Likun Wu
- Letian Lv
- Menglong Hu (ORCID: https://orcid.org/0000-0002-8419-613X)
- Yunsong Liu (ORCID: https://orcid.org/0000-0001-8364-1898)
- Hao Liu (ORCID: https://orcid.org/0000-0002-5181-7024)
- Xingtong Pan
- Erfan Wei
- Qiyue Zhu
- Xv Xiuyun
Institutions
- King University (US)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Aerospace Center Hospital (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s13287-025-04320-7
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22