The role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD
our study reveals that the molecular mechanism of dry AMD pathogenesis involves IGF2BP2-mediated NLRP3 inflammasome activation in macrophages, highlighting IGF2BP2 as a promising biomarker and therapeutic target for dry AMD treatment.
Authors
- Yi Qu (ORCID: https://orcid.org/0000-0003-4243-5785)
- Yifei Zhang (ORCID: https://orcid.org/0000-0003-2906-8159)
- Yuqing Zhao (ORCID: https://orcid.org/0000-0002-3856-8078)
- Junfang Li
- Yu Zhang (ORCID: https://orcid.org/0000-0001-8296-154X)
Institutions
- Shandong University (CN)
- Shanghai Clinical Research Center (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s13062-025-00648-5
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Shandong University
- Qilu Hospital of Shandong University