Refractory angina in women with ischemia and no obstructive coronary artery disease — A report from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study
Refractory angina is common in women with INOCA. Hypertension and endothelial-dependent microvascular dysfunction are independently associated with a 4- and 3-fold increase in refractory angina at 1-year, respectively. These findings may identify potential treatment targets to reduce angina burden in INOCA.
Authors
- Benita Tjoe (ORCID: https://orcid.org/0000-0001-9184-9437)
- Janet Wei (ORCID: https://orcid.org/0000-0002-1311-618X)
- Chrisandra Shufelt (ORCID: https://orcid.org/0000-0001-6886-9210)
- Jenna Maughan
- Carl J. Pepine (ORCID: https://orcid.org/0000-0002-6011-681X)
- Galen Cook‐Wiens (ORCID: https://orcid.org/0000-0003-4088-6240)
- Puja K. Mehta (ORCID: https://orcid.org/0000-0002-5678-812X)
- Eileen Handberg (ORCID: https://orcid.org/0000-0002-7805-9577)
- C. Noel Bairey Merz (ORCID: https://orcid.org/0000-0002-9933-5155)
- Daniel S. Berman (ORCID: https://orcid.org/0000-0002-9176-7535)
- Louise Thomson (ORCID: https://orcid.org/0000-0001-7492-7827)
- Judy Luu (ORCID: https://orcid.org/0000-0002-1429-0788)
- Anum Asif (ORCID: https://orcid.org/0000-0001-8241-5063)
Institutions
- Cedars-Sinai Medical Center (US)
- Emory University (US)
- McGill University Health Centre (CA)
- University of Florida (US)
- S. Mark Taper Foundation (US)
- Cedars-Sinai Smidt Heart Institute (US)
- Imaging Center (US)
Publication Details
- Journal
- American Heart Journal Plus Cardiology Research and Practice
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.ahjo.2025.100547
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00