Patient-derived organoids inform pharmacogenomic vulnerabilities in liver cancer
Patient-derived tumor organoids are a reliable model for preclinical and translational studies. Despite positive retrospective correlations with patient response data, challenges such as culture success, cost, standardization, and time constraints hinder their clinical utility in guiding precision medicine. This study underscores the utility of patient-derived organoids established from growth factor-reduced media in many facets of precision oncology, showing for the first time in hepatocellular carcinoma, clear benefit to patient survival in a proof-of-concept case study.
Authors
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Winnie Wing Yan Cheung
- Howard H.W. Leung (ORCID: https://orcid.org/0000-0001-9930-1783)
- Xiaofan Ding (ORCID: https://orcid.org/0000-0003-2565-7757)
- Alissa M. Wong (ORCID: https://orcid.org/0000-0001-7858-1368)
- Stephen L. Chan (ORCID: https://orcid.org/0000-0001-8998-5480)
- Yue Liu (ORCID: https://orcid.org/0000-0002-3192-6020)
- Yin Kau Lam (ORCID: https://orcid.org/0000-0002-3271-7685)
- Kelvin K. Ng (ORCID: https://orcid.org/0000-0002-3679-6368)
- Cecilia Ka Wing Chan (ORCID: https://orcid.org/0000-0003-0251-3750)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Luyao Zhang (ORCID: https://orcid.org/0000-0001-9408-9496)
- C. H. Chu
- Aikha Melissa Go Wong
- Anthony W.H. Chan (ORCID: https://orcid.org/0000-0002-1771-163X)
- Nathalie Wong (ORCID: https://orcid.org/0000-0003-2397-9189)
Institutions
- Chinese University of Hong Kong (HK)
- University of Macau (MO)
- Southeast University (BD)
- Southeast University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101426
- Citations
- 3
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.67