HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals
In a cohort of Black individuals, this study independently identified the same associations of peanut allergy and HLA that were previously observed in non-Hispanic White individuals. Our findings suggest that specific HLA binding groove amino acid polymorphisms may confer similar peanut allergy risk across population groups and HLA alleles.
Authors
- Jill A. Hollenbach (ORCID: https://orcid.org/0000-0001-6572-7962)
- David E. Lanfear (ORCID: https://orcid.org/0000-0001-6471-1483)
- Samantha Hochstadt
- Baojun Wu
- Elad Ziv (ORCID: https://orcid.org/0000-0002-2324-2884)
- B. Liu (ORCID: https://orcid.org/0009-0006-6860-5745)
- Donglei Hu
- Esteban G. Burchard (ORCID: https://orcid.org/0000-0001-7475-2035)
- Jonathan Witonsky (ORCID: https://orcid.org/0000-0001-8264-0244)
- Mao Yang
- Ray Zhang (ORCID: https://orcid.org/0000-0001-9668-3659)
- Rajesh Kumar
- L. Keoki Williams
Institutions
- Northwestern University (US)
- Lurie Children's Hospital (US)
- Henry Ford Health System (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jacig.2025.100485
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Asthma Foundation
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases