Slow releasing sulphide donor GYY4137 protects mice against ventilator-induced lung injury
In this mouse model of VILI, pretreatment with GYY4137 showed protective effects. GYY4137 significantly improved survival. It also improved arterial blood oxygenation and dynamic respiratory system compliance, and mitigated the development of lung oedema and inflammation.
Authors
- Jan A. Graw (ORCID: https://orcid.org/0000-0002-6920-8868)
- Roland C. E. Francis (ORCID: https://orcid.org/0000-0003-1958-9364)
- Lilly Veskemaa (ORCID: https://orcid.org/0000-0002-7026-0911)
- Adrián González-López (ORCID: https://orcid.org/0000-0001-5347-278X)
- Mahdi Taher (ORCID: https://orcid.org/0000-0001-8454-9751)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Ulm (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- University Hospital Ulm (DE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s40635-025-00753-9
- Citations
- 2
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Erlangen