A novel sex-specific association between insulin resistance and depressive symptoms in older adults: The potential mediating role of Vascular Endothelial Growth Factor
These findings suggest a sex-specific metabolic-inflammatory signature in late-life depression. VEGF may serve as a mechanistic link between IR and depressive symptoms in older women, supporting sex-tailored interventions.
Authors
- Michela Scamosci
- Patrizia Mecocci (ORCID: https://orcid.org/0000-0003-0729-5246)
- Virginia Boccardi (ORCID: https://orcid.org/0000-0003-2134-1122)
- Patrizia Bastiani
- Francesca Mancinetti
- Roberta Cecchetti
- Flavia Labarile
- Martina Alunno
Institutions
- University of Perugia (IT)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1016/j.jad.2025.04.115
- Citations
- 3
- Primary Topic
- Cardiac Health and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Università degli Studi di Perugia