Continuous Flow for the Photochemical Synthesis of 3-Substituted Quinolines
3-Cyano-quinolines are valuable building blocks in medicinal chemistry; however, their limited synthetic accessibility constrains their use. A new continuous-flow strategy was developed to safely obtain 3-cyanoquinolines from 2-(azidomethyl)-3-(aryl)prop-2-enenitriles within minutes. The versatility of our method was demonstrated by using a set of aromatic aldehydes as a starting material leading to previously unexplored quinolines with satisfactory yields.
Authors
- Barbara Balázs
- Miklós Nyerges (ORCID: https://orcid.org/0000-0001-9433-6872)
- Tamás Gáti (ORCID: https://orcid.org/0000-0002-7549-8291)
- Tamás Fődi (ORCID: https://orcid.org/0000-0002-5882-3371)
- Gergő Dargó (ORCID: https://orcid.org/0000-0002-1141-8379)
- János Tatai
- Márk Molnár (ORCID: https://orcid.org/0000-0003-4178-3251)
- Vilibald Kun
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1021/acs.oprd.4c00534
- Citations
- 2
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 1.35