Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia–reperfusion injury in mice
Our findings indicate that Piezo1 plays a crucial role in protecting against intestinal I/R injury by promoting angiogenesis in endothelial cells, possibly through the activation of the Ca<sup>2+</sup>/HIF-1α/VEGF signaling pathway. This suggests that targeting endothelial Piezo1 channels could be a therapeutic strategy for ileum I/R injury.
Authors
- Tianying Hong
- Jing Li (ORCID: https://orcid.org/0000-0002-0157-3041)
- Cuifen Wang
- Kai Hao (ORCID: https://orcid.org/0000-0002-8458-3404)
- Shangfei Luo
- Jiali Liu (ORCID: https://orcid.org/0009-0004-6492-9393)
- Ran An (ORCID: https://orcid.org/0000-0002-2417-0552)
- Jinze Li (ORCID: https://orcid.org/0000-0002-9693-3213)
- Yameng Yan
- Xin Sun (ORCID: https://orcid.org/0000-0001-7035-593X)
- Weipin Niu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- New York College of Health Professions (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s10020-025-01197-3
- Citations
- 4
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Natural Science Foundation of China