Serological Analysis Indicating the Exposure of Two Volunteers to Relapsing Fever Borrelia sp. in Nayarit, Mexico
Relapsing fever caused by Borrelia sp. is a neglected disease in Mexico and more studies are needed to update its presence in multiple regions of the country. Here, recombinant proteins glycerophosphodiester phosphodiesterase (GlpQ) and three Borrelia immunogenic protein A (BipA) variants were used for serosurveillance in 142 human serum samples. Results showed that two persons were positive to Borrelia extracts and GlpQ but negative to all three BipA, suggesting they were infected by relapsing fever spirochetes of a yet to be determined species. This shows that testing for GlpQ and Borrelia extracts are a useful tool for potential infections and grants their use in other regions and studies in Mexico.
Authors
- Jeanet Serafín‐López (ORCID: https://orcid.org/0000-0003-2736-2688)
- Javier Hernández (ORCID: https://orcid.org/0000-0003-2498-4449)
- Fernando Martínez‐Hernández (ORCID: https://orcid.org/0000-0002-6140-8398)
- Sofía L. Luna-Rojas
- Rigoberto Hernández‐Castro (ORCID: https://orcid.org/0000-0002-5656-0942)
- J. Antonio Ibarra (ORCID: https://orcid.org/0000-0002-5016-0622)
- José Alejandro Martínez‐Ibarra (ORCID: https://orcid.org/0000-0002-6600-654X)
- Edwin Vázquez-Guerrero (ORCID: https://orcid.org/0000-0003-4092-5158)
- Job E. López (ORCID: https://orcid.org/0000-0003-4802-5779)
Institutions
- Baylor College of Medicine (US)
- Universidad de Guadalajara (MX)
- Hospital General Dr. Manuel Gea Gonzalez (MX)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- American Journal of Tropical Medicine and Hygiene
- Published
- 2025-04-22
- DOI
- https://doi.org/10.4269/ajtmh.24-0636
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00