Dehydroabietic acid protects against cerebral ischaemia–reperfusion injury by modulating microglia‐mediated neuroinflammation via targeting PKCδ
DHA specifically interacts with PKCδ, preventing its phosphorylation induced by ischaemia-reperfusion injury. These results suggest that DHA is a novel inhibitor of PKCδ and provide solid experimental foundations for using DHA in treating neuroinflammation-related conditions, such as CIRI.
Authors
- Lingyu She
- Xia Zhao (ORCID: https://orcid.org/0000-0002-7980-8592)
- Luyao Li (ORCID: https://orcid.org/0000-0002-0250-8428)
- Yuqing Zeng (ORCID: https://orcid.org/0000-0001-8768-4764)
- Linjie Chen (ORCID: https://orcid.org/0009-0007-7431-4490)
- Yi Wang (ORCID: https://orcid.org/0000-0001-9921-0304)
- Hao Tang (ORCID: https://orcid.org/0000-0002-3203-9773)
- Namki Cho (ORCID: https://orcid.org/0000-0002-9936-3463)
- Qin Yu (ORCID: https://orcid.org/0000-0002-3946-262X)
- Zhen Lin (ORCID: https://orcid.org/0009-0004-6678-786X)
- Fan Chen
- Guang Liang (ORCID: https://orcid.org/0009-0005-1603-3223)
Institutions
- Chonnam National University (KR)
- Hangzhou Normal University (CN)
- Wenzhou Medical University (CN)
- Nanfang Hospital (CN)
- Hangzhou Medical College (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1111/bph.70030
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84